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KMID : 1189420100230030033
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Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology
2010 Volume.23 No. 3 p.33 ~ p.41
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Experimental study about the effect of several herbs on collagen synthesis
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Yoon Ji-Eun
Kim Nam-Kwen
Hwang Choong-Yeon
Jo Eun-Hee
Park Min-Cheol
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Abstract
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Background and Objective :This study was performed to find a new anti-aging, anti-wrinkle agent. Ten kinds of hers were evaluated by proliferation, cytotoxicity, collagen synthesis tests in cultured human dermal fibroblast.
Methods: MTT assay was carried out to check cell proliferation, cytotoxic effect of each herbal medicine. Collagen synthesis was investigated by the amount of propeptide using procollagen type-Ⅰ C peptide(PIP) ELISA kit(Takara).
Results and ConclusionsThere are no cytotoxicity in all group herbs by MTT assay. Collagen synthetic ability was greatest in LYCII FRUCTUS(LF) and was excellent in order of Rehmanniae Radix Preparat(RRP) > Nelumbinis Semen(NS) > Asparai Radix(AR) > Schizandrae Frucus(SF).
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KEYWORD
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HDF, anti-aging, anti-wrinkle, collagen synthesis
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